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Canadian Journal of Infectious Diseases and Medical Microbiology
Volume 19, Issue 6, Pages 419-423

A Review of Influenza Vaccine Immunogenicity and Efficacy in HIV-Infected Adults

Curtis Cooper,1 Brian Hutton,1 Dean Fergusson,1 Edward Mills,2 Marina B Klein,3 Guy Boivin,4 and Scott Halperin5

1University of Ottawa, Division of Infectious Diseases – The Ottawa Hospital, Ottawa Health Research Institute – Methods Centre, Ottawa, Ontario, Canada
2The University of British Columbia, Vancouver, British Columbia, Canada
3McGill University, Montreal, Canada
4Laval University, Laval, Quebec, Canada
5Dalhousie University, Halifax, Nova Scotia, Canada

Received 11 March 2008; Accepted 17 July 2008

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


BACKGROUND: HIV-seropositive adults are at an increased risk for influenza infection. They also develop more severe influenza disease and are hyporesponsive to current influenza vaccinations.

METHODS: The authors examined findings from a systematic review of influenza vaccination in HIV-seropositive adults, and evaluated other relevant studies. A narrative overview of findings formulated to summarize the implications of currently available literature is presented. The primary goal of the present review is to assess the limitations of current evidence and to provide a framework for additional research.

RESULTS: There is a paucity of knowledge regarding the relative value of prophylactic influenza vaccination in HIV-positive adults compared with immunocompetent populations. There are shortcomings related to study methodology and temporal changes in the characteristics of patient baseline immune status, which limit the utility of this information to shape public health policy.

CONCLUSIONS: There is a pressing need to pursue methodologically rigorous studies that will increase knowledge related to improving the effectiveness of preventive influenza measures in this patient population.