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Canadian Journal of Infectious Diseases and Medical Microbiology
Volume 19, Issue 2, Pages 203-205
http://dx.doi.org/10.1155/2008/787689
Case Report

Fatal Disseminated Trichosporon asahii Infection in a Child with Acute Lymphoblastic Leukemia

Roseline Thibeault,1 Martin Champagne,2 Louis de Repentigny,3 Jean-Christophe Fournet,4 Bruce Tapiero,1 Albert Moghrabi,2 and Philippe Ovetchkine1

1Infectious Diseases Division, Université de Montréal, Montreal, Quebec, Canada
2Hematology-Oncology Division, Department of Pediatrics, Université de Montréal, Montreal, Quebec, Canada
3Department of Microbiology and Immunology, Université de Montréal, Montreal, Quebec, Canada
4Department of Pathology, CHU Sainte Justine, Université de Montréal, Montreal, Quebec, Canada

Received 12 July 2007; Accepted 26 November 2007

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Few cases of Trichosporon species infection have been reported in children. The present report describes a case of fatal disseminated Trichosporon asahii infection in a child treated for relapsed leukemia. Voriconazole has previously shown promising activity in vitro, and has been used successfully in the treatment of T asahii infections. The patient died five days after voriconazole treatment was started, and the autopsy revealed widespread systemic dissemination to all organs.