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Canadian Journal of Infectious Diseases and Medical Microbiology
Volume 21, Issue 4, Pages e122-e150
http://dx.doi.org/10.1155/2010/357076
Ammi Canada Guidelines

Canadian Clinical Practice Guidelines for Invasive Candidiasis in Adults

Eric J Bow,1 Gerald Evans,2 Jeff Fuller,3 Michel Laverdière,4 Coleman Rotstein,5 Robert Rennie,3 Stephen D Shafran,6 Don Sheppard,7 Sylvie Carle,8 Peter Phillips,9 and Donald C Vinh10

1Department of Medical Microbiology and Infectious Diseases, University of Manitoba; Clinical and Academic Services, and Infection Control Services, Cancer Care Manitoba; Oncology Program, Winnipeg Regional Health Authority, Winnipeg, Manitoba, Canada
2Division of Infectious Diseases, Department of Medicine, Queen’s University, Kingston General Hospital, Kingston, Ontario, Canada
3Department of Laboratory Medicine and Pathology, University of Alberta, University of Alberta Hospital, Edmonton, Alberta, Canada
4Department of Microbiology-Infectious Diseases, University of Montreal, Laboratory Program, Hôpital Maisonneuve-Rosemont, Montreal, Quebec, Canada
5Division of Infectious Disease, Department of Medicine, University of Toronto and Transplant Infectious Diseases, Oncologic Infectious Diseases, University Health Network, Toronto, Ontario, Canada
6Division of Infectious Diseases, Department of Medicine, University of Alberta, Capital Health Authority, Edmonton, Alberta, Canada
7Departments of Medicine, and Microbiology and Immunology, McGill University, Montreal, Quebec, Canada
8Department of Pharmacy, University of Montreal, McGill University Health Centre, Montreal, Quebec, Canada
9Division of Infectious Diseases, Department of Medicine, University of British Columbia, St Paul’s Hospital, Vancouver, British Columbia, Canada
10Division of Infectious Diseases, Department of Medicine, Department of Medical Microbiology, McGill University, Montreal, Quebec and Laboratory of Clinical Infectious Diseases, Canada

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Candidemia and invasive candidiasis (C/IC) are life-threatening opportunistic infections that add excess morbidity, mortality and cost to the management of patients with a range of potentially curable underlying conditions. The Association of Medical Microbiology and Infectious Disease Canada developed evidence-based guidelines for the approach to the diagnosis and management of these infections in the ever-increasing population of at-risk adult patients in the health care system. Over the past few years, a new and broader understanding of the epidemiology and pathogenesis of C/IC has emerged and has been coupled with the availability of new antifungal agents and defined strategies for targeting groups at risk including, but not limited to, acute leukemia patients, hematopoietic stem cell transplants and solid organ transplants, and critical care unit patients. Accordingly, these guidelines have focused on patients at risk for C/IC, and on approaches of prevention, early therapy for suspected but unproven infection, and targeted therapy for probable and proven infection.