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Canadian Journal of Infectious Diseases and Medical Microbiology
Volume 24, Issue 2, Pages 109-112
Case Report

Successful Use of Locally Applied Polyhexamethylene Biguanide as an Adjunct to the Treatment Of Fungal Osteomyelitis

Genevieve Walls,1 Lisa Noonan,1 Elizabeth Wilson,2 David Holland,3 and Simon Briggs1

1Department of Infectious Diseases, Auckland City Hospital, Auckland, New Zealand
2Department of Infectious Diseases, Starship Children’s Hospital, Auckland, New Zealand
3Department of Infectious Diseases, Middlemore Hospital, Auckland, New Zealand

Copyright © 2013 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Fungal osteomyelitis is rare in immunocompetent patients and is often difficult to cure, even with optimal medical and surgical management. The authors present two cases of fungal osteomyelitis in which the common swimming pool cleaner, polyhexamethylene biguanide, was used successfully as an adjunct to standard surgical and medical treatment. Also presented is a literature review on the use of polyhexamethylene biguanide for this indication. The authors recommend that this safe and well-tolerated compound be considered as part of the treatment for fungal osteomyelitis.