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Canadian Journal of Infectious Diseases and Medical Microbiology
Volume 24 (2013), Issue 3, Pages e50-e52
Original Article

Assessment of Linezolid Efficacy, Safety and Tolerability in the Treatment of Tuberculosis: A Retrospective Case Review

Alena Tse-Chang,1 Dennis Kunimoto,2 Evelina Der,3 and Rabia Ahmed2

1Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
2Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
3Central TB Services, Alberta Health Services, Edmonton, Alberta, Canada

Copyright © 2013 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Linezolid is a potentially effective drug for the treatment of patients with drug-resistant tuberculosis. Among 13 patients treated for tuberculosis with linezolid in the present study, nine had treatment success and four remain on treatment. Adverse effects occurred in 11 (85%) patients, of whom three discontinued treatment because of adverse effects. The present study adds to the growing evidence supporting the efficacy of linezolid for tuberculosis, although treatment remains complicated by adverse effects.