Review Article
Fosfomycin: A First-Line Oral Therapy for Acute Uncomplicated Cystitis
Table 4
Pharmacokinetic properties of fosfomycin following a single 3-gram oral dose
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| Parameter | Mean value or range |
| Serum/plasma | | Bioavailability () | 34–41% | Maximum plasma concentration | 22–32 g/mL | Time to maximum concentration in the blood () | 2–2.5 h | Area under the curve (AUC) | 145 mg/L⋅h | Volume of distribution () | 136.1 L | Half-life () | 5.7 h | Clearance (CL) | 16.9 L/h |
| Urine | | Maximum urinary concentration () | 1053–4415 g/mL | Time to maximum concentration in the urine (urinary ) | 4 h | Urinary concentration at 48 h | ~100 g/mL |
| Dosage adjustments | | Dose adjustment in elderly | None required | Dose adjustment in pregnancy | None required | Dose adjustment for renal impairment | None required | Hepatic adjustment | None required |
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Data adapted from [14, 48, 49].
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