Fosfomycin: A First-Line Oral Therapy for Acute Uncomplicated Cystitis

Table 4

Pharmacokinetic properties of fosfomycin following a single 3-gram oral dose.

Parameter	Mean value or range
Serum/plasma
Bioavailability ()	34–41%
Maximum plasma concentration	22–32 g/mL
Time to maximum concentration in the blood ()	2–2.5 h
Area under the curve (AUC)	145 mg/L⋅h
Volume of distribution ()	136.1 L
Half-life ()	5.7 h
Clearance (CL)	16.9 L/h
Urine
Maximum urinary concentration ()	1053–4415 g/mL
Time to maximum concentration in the urine (urinary )	4 h
Urinary concentration at 48 h	~100 g/mL
Dosage adjustments
Dose adjustment in elderly	None required
Dose adjustment in pregnancy	None required
Dose adjustment for renal impairment	None required
Hepatic adjustment	None required

Data adapted from [14, 48, 49].