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Canadian Journal of Infectious Diseases and Medical Microbiology
Volume 2016, Article ID 2373424, 7 pages
http://dx.doi.org/10.1155/2016/2373424
Research Article

Spectrum of Opportunistic Fungal Infections in HIV/AIDS Patients in Tertiary Care Hospital in India

1Department of Microbiology, Lady Hardinge Medical College and Associated Hospitals, New Delhi 110001, India
2Department of Microbiology, Maulana Azad Medical College and Associated Lok Nayak Hospitals, New Delhi 110002, India
3Department of Medicine, Maulana Azad Medical College and Associated Lok Nayak Hospitals, New Delhi 110002, India

Received 2 February 2016; Revised 10 May 2016; Accepted 30 May 2016

Academic Editor: Maria L. Tornesello

Copyright © 2016 Ravinder Kaur et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

HIV related opportunistic fungal infections (OFIs) continue to cause morbidity and mortality in HIV infected patients. The objective for this prospective study is to elucidate the prevalence and spectrum of common OFIs in HIV/AIDS patients in north India. Relevant clinical samples were collected from symptomatic HIV positive patients () of all age groups and both sexes and subjected to direct microscopy and fungal culture. Identification as well as speciation of the fungal isolates was done as per the standard recommended methods. CD4+T cell counts were determined by flow cytometry using Fluorescent Activated Cell Sorter Count system. 215 fungal isolates were isolated with the isolation rate of 41.1%. Candida species (86.5%) were the commonest followed by Aspergillus (6.5%), Cryptococcus (3.3%), Penicillium (1.9%), and Alternaria and Rhodotorula spp. (0.9% each). Among Candida species, Candida albicans (75.8%) was the most prevalent species followed by C. tropicalis (9.7%), C. krusei (6.4%), C. glabrata (4.3%), C. parapsilosis (2.7%), and C. kefyr (1.1%). Study demonstrates that the oropharyngeal candidiasis is the commonest among different OFIs and would help to increase the awareness of clinicians in diagnosis and early treatment of these infections helping in the proper management of the patients especially in resource limited countries like ours.