CIHR Canadian HIV Trials Network Coinfection and Concurrent Diseases Core Research Group: 2016 Updated Canadian HIV/Hepatitis C Adult Guidelines for Management and Treatment
Table 1
Grading system for recommendations.
Classification description
Class of evidence
Class 1
Conditions for which there is evidence and/or general agreement that a given diagnostic evaluation procedure or treatment is beneficial, useful, and effective
Class 2
Conditions for which there is conflicting evidence and/or a divergence of opinion about the usefulness/efficacy of a diagnostic evaluation, procedure, or treatment
Class 2a
Weight of evidence/opinion is in favour of usefulness/efficacy
Class 2b
Usefulness/efficacy is less well established by evidence/opinion
Class 3
Conditions for which there is evidence and/or general agreement that a diagnostic evaluation and procedure/treatment is not useful/effective and in some cases may be harmful
Grade of evidence
Level A
Data derived from multiple randomized clinical trials or meta-analyses
Level B
Data derived from a single randomized trial or nonrandomized studies
Level C
Only consensus opinions of experts, case studies, or standard-of-care
