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Canadian Journal of Infectious Diseases and Medical Microbiology
Volume 2017, Article ID 1671607, 6 pages
https://doi.org/10.1155/2017/1671607
Review Article

Roles of Interferons in Pregnant Women with Dengue Infection: Protective or Dangerous Factors

1Department of Infectious Diseases, The Key Discipline of Guangdong Province, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, No. 151 Yanjiang Road, Guangdong Province 510120, China
2Department of Obstetrics and Gynecology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, No. 151 Yanjiang Road, Guangdong Province 510120, China
3Guangdong Provincial Key Laboratory of Tropical Disease Research and Key Laboratory of Prevention and Control for Emerging Infectious Diseases of Guangdong Higher Institutes, School of Public Health and Tropical Medicine, Southern Medical University, No. 1023 South Shatai Road, Guangzhou, Guangdong Province 510515, China

Correspondence should be addressed to Wenting Zeng; moc.361@55854690631 and Hong-Juan Peng; nc.ude.ums@naujgnoh

Received 15 June 2017; Revised 1 August 2017; Accepted 6 August 2017; Published 7 September 2017

Academic Editor: Maria L. Tornesello

Copyright © 2017 Hao Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Dengue infection is a serious public health problem in tropical and subtropical areas. With the recent outbreaks of Zika disease and its reported correlation with microcephaly, the large number of pregnancies with dengue infection has become a serious concern. This review describes the epidemiological characteristics of pregnancy with dengue and the initial immune response to dengue infection, especially in IFNs production in this group of patients. Dengue is much more prevalent in pregnant women compared with other populations. The severity of dengue is correlated with the level of IFNs, while the serum IFN level must be sufficiently high to maintain the pregnancy and to inhibit virus replication.