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Canadian Journal of Infectious Diseases and Medical Microbiology
Volume 2017 (2017), Article ID 2309478, 9 pages
https://doi.org/10.1155/2017/2309478
Review Article

Inflammasomes in Mycobacterium tuberculosis-Driven Immunity

Division of Cell Immunology, Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland

Correspondence should be addressed to Sebastian Wawrocki

Received 3 July 2017; Revised 30 September 2017; Accepted 18 October 2017; Published 4 December 2017

Academic Editor: Maria L. Tornesello

Copyright © 2017 Sebastian Wawrocki and Magdalena Druszczynska. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The development of effective innate and subsequent adaptive host immune responses is highly dependent on the production of proinflammatory cytokines that increase the activity of immune cells. The key role in this process is played by inflammasomes, multimeric protein complexes serving as a platform for caspase-1, an enzyme responsible for proteolytic cleavage of IL-1β and IL-18 precursors. Inflammasome activation, which triggers the multifaceted activity of these two proinflammatory cytokines, is a prerequisite for developing an efficient inflammatory response against pathogenic Mycobacterium tuberculosis (M.tb). This review focuses on the role of NLRP3 and AIM2 inflammasomes in M.tb-driven immunity.