In Vitro Antibacterial Interaction of Doripenem and Amikacin against Multidrug-Resistant Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae Isolates

Table 3

Mean MIC changes after combining doripenem and amikacin.

Bacteria	MICDOR	MICDOR+AMK	Mean difference	value	MICAMK	MICAMK+DOR	Mean difference	value
DOR-S/AMK-S
A. baumannii	0.37	0.13	0.24	0.001	2.33	0.88	1.45	0.008
P. aeruginosa	0.66	0.32	0.34	0.006	4.00	1.69	2.31	0.003
K. pneumoniae	0.29	0.09	0.20	0.027^	3.25	2.42	0.83	0.041^
DOR-S/AMK-R
A. baumannii	4.08	2.33	1.75	0.073	121.33	92.67	28.67	0.221
P. aeruginosa	4.00	3.00	1.00	0.157^	256.00	192.00	64.00	0.157
K. pneumoniae	0.09	0.06	0.03	0.033	217.33	162.67	54.66	0.035
DOR-R/AMK-S
A. baumannii	32.00	29.33	2.67	0.363	3.58	2.75	0.83	0.129
P. aeruginosa	32.00	27.67	4.33	0.363	9.00	7.67	1.33	0.363
K. pneumoniae	26.67	9.12	17.50	0.001	2.50	1.50	1.00	0.018
DOR-R/AMK-R
A. baumannii	32.00	32.00	0.00	0.317^	256.00	256.00	0.00	0.109^
P. aeruginosa	32.00	27.33	4.67	0.180	141.33	128.00	13.33	0.180
K. pneumoniae	23.33	21.33	2.00	0.203	256.00	220.33	26.67	0.363

Paired t-test; ^Wilcoxon’s signed-rank test.