Canadian Journal of Infectious Diseases and Medical Microbiology / 2018 / Article / Tab 1

Review Article

Oral Fosfomycin for the Treatment of Acute and Chronic Bacterial Prostatitis Caused by Multidrug-Resistant Escherichia coli

Table 1

In vitro activities of orally prescribed antimicrobial agents against urine isolates of E. coli collected by 15 clinical laboratories across Canada from 2007 to 2015a.

E. coli phenotypeb (n)Antimicrobial agentCLSI MIC interpretationf
% S% I% R

All E. coli (1,207)Fosfomycin99.20.70.1
AMCc87.19.63.3
Ciprofloxacin81.1018.9
TMP-SMXd7525
TMP-SMX-resistant (302)Fosfomycin99.71.31
AMC74.822.23
Ciprofloxacin57.6042.4
TMP-SMX00100
Ciprofloxacin-resistant (228)Fosfomycin96.10.43.5
AMC71.522.85.7
Ciprofloxacin0100100
TMP-SMX43.956.1
ESBL-positive (61)Fosfomycin95.14.90
AMC63.932.83.3
Ciprofloxacin16.4083.6
TMP-SMX34.465.6
AMC-resistant (40)Fosfomycin10000
AMC00100
Ciprofloxacin67.5032.5
TMP-SMX77.522.5
Resistant to TMP-SMX and CIPe (128)Fosfomycin97.70.71.6
AMC66.428.94.7
Ciprofloxacin00100
TMP-SMX00100
Resistant to CIP and AMC (13)Fosfomycin10000
AMC00100
Ciprofloxacin00100
TMP-SMX53.846.2
Resistant to TMP-SMX and AMC (9)Fosfomycin10000
AMC00100
Ciprofloxacin33.3066.7
TMP-SMX00100
Multidrug-resistant (12)Fosfomycin10000
AMC16.733.350
Ciprofloxacin00100
TMP-SMX00100

aData adapted from reference [4]; bESBL, extended-spectrum β-lactamase; multidrug-resistant was defined as isolates resistant to ≥3 agents from different antimicrobial classes (amoxicillin-clavulanate, ciprofloxacin, nitrofurantoin, and TMP-SMX); cAMC, amoxicillin-clavulanate; dTMP-SMX, trimethoprim-sulfamethoxazole; eCIP, ciprofloxacin; fbased on CLSI fosfomycin MIC breakpoints for E. coli: susceptible, ≤64 μg/mL; intermediate, 128 μg/mL; and resistant, ≥256 μg/mL (CLSI, M100-S26, 2016).

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.