Elevated Serum Total Bilirubin Level Is Associated with Poor Outcomes in Pediatric Patients with Sepsis-Associated Liver Injury
Table 1
Demographic and clinical characteristics of the patients enrolled in this study.
Characteristics
Survivor ()
Nonsurvivor ()
P
Age, month, median (IQR)
12 (7, 33)
18 (10, 84)
0.213
Male, n (%)
30 (65.2)
13 (50)
0.206
Source of sepsis
Lungs, n (%)
25 (54.3)
11 (42.3)
0.326
Abdominal, n (%)
13 (28.3)
11 (42.3)
0.225
CNS, n (%)
4 (8.7)
1 (3.8)
0.437
Haematogenous, n (%)
2 (4.3)
2 (7.7)
0.552
Skin/soft tissues, n (%)
2 (4.3)
1 (3.8)
0.919
Pediatric risk of mortality III (PRISM III), median (IQR)
10 (5, 13)
12.5 (9, 19)
0.058
Complications
Hemophagocytic syndrome, n (%)
7 (15.2)
5 (19.2)
0.661
Hematologic malignancy, n (%)
4 (8.7)
4 (15.4)
0.386
Adjuvant treatment
CRRT, n (%)
13 (28.3)
6 (23.1)
0.632
Mechanical ventilation, n (%)
17 (40.0)
18 (69.2)
0.008
Transferred from the other ward, n (%)
14 (30.4)
6 (23.1)
0.503
MAP (mmHg)
67 (61–73)
66 (57–76)
0.518
PaO2/FiO2 (mmHg)
331 (241–410)
300 (203–365)
0.078
sCr (μmol/L)
26.5 (20.0–43.0)
31.5 (22.0–48.0)
0.443
BUN (mmol/L)
4.2 (2.9–7.1)
5.5 (3.2–11.0)
0.212
Lac (mg/dL)
2.3 (1.3–3.6)
2.7 (1.4–5.2)
0.303
PLT(109/L)
183 (119–333)
157 (57–208)
0.199
Major pathogen
Gram-negative bacterium
22
13
0.859
Acinetobacter baumannii
7
5
Pseudomonas aeruginosa
5
2
Klebsiella pneumoniae
3
3
Haemophilus influenzae
4
0
Enterobacter cloacae
0
2
Others
3
1
Virus
14
4
0.157
EBV
11
3
CMV
3
1
Gram-positive bacterium
8
4
0.826
Streptococcus pneumoniae
1
2
Staphylococcus aureus
2
1
Enterococcus gallinarum
2
0
Enterococcus faecium
1
1
Staphylococcus capitis
1
0
Others
1
0
Mycoplasma
2
1
0.919
CNS: central nervous system; CRRT: continuous renal replacement therapy; MAP: mean arterial pressure; PaO2/FiO2: the ratio of the partial pressure of oxygen in arterial blood (PaO2) to the inspired oxygen fraction (FiO2); sCr: serum creatinine; BUN: blood urea nitrogen; Lac: lactate; PLT: platelet. Indicated that data were treated with Ln processing.
