Cryptococcal Meningitis: A Retrospective Cohort of a Brazilian Reference Hospital in the Post-HAART Era of Universal Access

Table 1

Baseline characteristics of 79 patients with cryptococcal meningitis.

Variable
Age, years; mean (range)	37 (5–67)
Age ≥50 years; N (%)	17 (21.5)
Sex, male N (%)	45 (56.9)
Time of hospitalization,days; mean (range)	28 (1–149)
Type of immunosuppression	(%)
HIV	65 (82.3)
SOTR	8 (10.1)
NHNT	6 (7.6)
HIV patients
Dx during hospitalization^a	14 (17.7)
Vertical transmission of HIV	3 (3.7)
Receiving HAART at Dx	34 (43.0)
CD4, cells/mm³ mean (range)	34 (3–428)
HIV viral load, log; mean (range)	5.01 (2.18–6.16)
SOTR patients	(%)
Kidney	5 (10.1)
Liver	3 (10.1)
Duration of transplant, years
General; mean (range)	2.12 (0–7.35)
Kidney; mean (range)	3.58 (0.25–7.36)
Liver; mean (range)	2.12 (0–7.35)
Other concomitante conditions	(%)
Use of corticosteroids	8 (10.1)
Chronic kidney disease	2 (2.5)
Cancer	4 (5.1)
Rheumatic disease	2 (2.5)
Diabetes mellitus	3 (3.8)
Cirrhosis	2 (2.5)
Cryptococcus species complex
C. neoformans	76 (96.2)
C. gattii	3 (3.8)
Duration of symptoms, days; mean (range)	10 (1–120)
Rehospitalization	6 (7.5)
30-day mortality	15 (19.1)
60-day mortality	19 (24.4)

SOTR, solid organ transplant recipients; NHNT, non-HIV nontransplant; ESRD, end-stage renal disease. ^aDiagnosis of HIV concomitant with neurocryptococcosis.