Accuracy of Enzyme-Linked Immunosorbent Assays (ELISAs) in Detecting Antibodies against Mycobacterium leprae in Leprosy Patients: A Systematic Review and Meta-Analysis
Table 1
A summary of the included studies.
Antigen
Journal
Year
Author
Country
Method
Dilution
Cut-off
TP/total
FN/total
OD
MB
PB
EC
PGL-1
Aust. NZ J Med
1987
Britton
Australia and Nepal
Conventional
1/100
>0.15
33/44
1/4
0/60
Int. J. Lepr.
1988
Wu
China
Conventional
1/200
>0.04
76/76
40/40
0/30
Int. J. Lepr.
1990
Wu
China
Conventional
1/201
>0.2
70/90
11/20
1/30
Asian Pac J Allergy Immunol.
1990
Praputpittaya
Thailand
Conventional
1/300
>0.056
23/28
5/18
0/33
Mem. Inst. Oswaldo Cruz
1990
Saad
Brazil
Conventional
1/4000
>0.27
61/74
6/52
4/52
Lepr. Rev.
1991
Chanteau
French Polynesia
Conventional
1/200
>0.2
20/21
8/23
9/414
BMC Infect. Dis.
2013
Vaz Cardoso
Brazil
Conventional
1/300
>0.250
90/108
16/104
1/30
Lepr. Rev.
2003
Torres
Spain
Conventional
1/300
>0.160
15/50
0/10
1/40
PLoS Neglected Trop. Dis
2017
Frade
Brazil
Conventional
1/400
0.1
15/33
5/7
67/245
ND-O-BSA
Int. J. Lepr.
1988
Wu
China
Conventional
1/200
>0.05
76/76
37/40
0/30
Int. J. Lepr.
1990
Wu
China
Conventional
1/201
>0.2
70/90
11/20
1/30
Asian Pac. J. Allergy Immunol.
1990
Praputpittaya
Thailand
Conventional
1/300
>0.056
23/28
5/18
0/33
Int. J. Lepr.
1993
Cellona
Philippines
Conventional
—
0.16
163/193
22/147
7/401
Int. J. Lepr.
2002
Wu
China
Conventional
1/200
—
53/53
46/50
0/100
Am. J. Trop. Med. Hyg.
2013
Wen
China
Conventional
—
>0.2
48/49
21/30
1/35
J. Immunol. Methods
2014
Moura
Brazil
Conventional
>0.2
375/486
88/342
0/69
+LID-1
Clin. Vaccine Immunol.
2007
Duthie
Brazil
Conventional
1/1000
0.1
26/30
6/30
1/26
Mem. Inst. Oswaldo Cruz
2012
Hungria
Brazil
Conventional
1/200
0.3
51/58
6/93
7/282
Am. J. Trop. Med. Hyg.
2013
Wen
China
Conventional
—
>0.2
44/49
16/30
0/35
Biomed Res. Int.
2014
Wen
China
Conventional
1/200
>2 × SD OD EC
7/20
8/11
0/10
PLoS Neglected Trop. Dis
2016
Amorim
Brazil
Conventional
1/200
>3 × SD OD EC
58/68
5/32
1/98
Diagn Microbiol. Infect. Dis.
2016
Freitas
Brazil
Conventional
1/200
0.3
42/48
4/60
0/62
Diagn Microbiol. Infect. Dis.
2017
Hungria
Brazil
Conventional
1/200
0.3
24/30
1/38
2/61
PLoS Neglected Trop. Dis.
2017
Frade
Brazil
Conventional
1/400
0.1
15/33
5/7
67/245
Type of sample used: plasma. All other studies used serum. TP/total = true positive/total of cases; FN/total = false negative/total of endemic control; EC = endemic control; +LID-1: Developed by Infectious Disease Research Institute (IDRI).
