Accuracy of Enzyme-Linked Immunosorbent Assays (ELISAs) in Detecting Antibodies against Mycobacterium leprae in Leprosy Patients: A Systematic Review and Meta-Analysis

Table 2

Accuracy of ELISAs for detection of leprosy using different M. leprae antigens. Summary points of the HSROC curve accuracy for each M. leprae antigen used in the ELISAs for each population studied.

ELISA antigen/Op. class	Sensitivity %	95% CI	Specificity %	95% CI	LR+	95% CI	LR−	95% CI	DOR	95% CI
PGL-I
MB	78	60–90	99	91–99	90	8–1023	0.22	0.11–0.44	408	23–7041
PB	34	11–67	97	89–99	16	2–121	0.67	0.42–1	22	2.4–247
ND-O-BSA
MB	94	78–98	99	97–99	129	42–390	0.05	0.01–0.23	2293	279–18844
PB	56	27–81	99	98–99	76	21–274	0.43	0.21–0.87	174	39–1013
LID-1
MB	79	66–88	97	91–99	26	8–90	0.2	0.11–0.37	127	22–721
PB	20	7–46	97	92–99	8	3.0–24	0.81	0.64–1	9.8	2.8–33

Op. class = operational classification; 95% CI = 95% confidence interval; LR− = negative likelihood; LR+ = positive likelihood ratio; DOR = diagnostic odds ratio.