Canadian Journal of Infectious Diseases and Medical Microbiology / 2019 / Article / Tab 1

Research Article

Association between Elevated Serum Tau Protein Level and Sepsis-Associated Encephalopathy in Patients with Severe Sepsis

Table 1

Baseline demographic and clinical findings between the SAE and non-SAE groups.

ItemsTotal (n = 109)SAE (n = 27)Non-SAE (n = 82) value

Age, y, mean ± SD61.7 ± 13.064.4 ± 14.257.8 ± 12.50.142

Male/Female64/4516/1148/340.386

Disease severity, mean ± SD
 APACHE II score18.4 ± 5.221.8 ± 6.715.2 ± 4.60.013
 SOFA score6.3 ± 3.18.7 ± 2.64.8 ± 3.3<0.001

Inflammatory markers
 WBC, mean ± SD (×109/L)15.24 ± 9.9016.54 ± 9.6713.81 ± 10.170.373
 PCT, mean ± SD (ng/mL)35.24 ± 27.8130.77 ± 26.3238.24 ± 30.460.214
 CRP, mean ± SD (mg/L)193.84 ± 91.21196.92 ± 87.84188.47 ± 96.450.307

Biochemistry
 Lactate, mean ± SD (mmol/L)3.12 ± 2.033.86 ± 2.122.40 ± 1.710.011
 Glucose, mean ± SD (mmol/L)8.95 ± 3.079.35 ± 3.328.71 ± 2.690.413
 Creatinine, mean ± SD (μmol/L)135.74 ± 28.61142.46 ± 31.40126.45 ± 26.910.092
 BUN, mean ± SD (mmol/L)12.27 ± 9.7613.08 ± 10.2611.44 ± 9.340.194
 Albumin, mean ± SD (g/L)25.06 ± 5.8624.75 ± 6.2826.35 ± 5.320.316
 Total bilirubin, mean ± SD (mmol/L)22.31 ± 5.8224.52 ± 6.3321.41 ± 5.060.481
 AST, median (range) (U/L)346 (43–12016)395 (48–12016)320 (43–9830)0.106
 ALT, median (range) (U/L)156 (25–8900)172 (25–8900)142 (34–7500)0.085
 Cholesterol, mean ± SD (mmol/L)3.44 ± 0.472.78 ± 0.424.01 ± 0.500.126
 BNP, median (range) (pg/mL)1710 (520–12800)1740 (570–12800)1630 (520–9200)0.124
 pH, mean ± SD7.40 ± 0.117.39 ± 0.097.40 ± 0.130.437
 PaO2, mean ± SD (mmHg)77.26 ± 43.2178.32 ± 44.8576.37 ± 42.090.753
 PaCO2, mean ± SD (mmHg)43.02 ± 19.4342.65 ± 18.4444.69 ± 20.790.321
 HCO3, mean ± SD (mmol/L)24.01 ± 4.0525.62 ± 4.2123.18 ± 3.500.416

Infection sites0.473
 Respiratory system39 (35.8)9 (33.3)30 (36.6)
 Urinary system32 (29.4)6 (22.3)26 (31.7)
 Blood17 (15.6)5 (18.5)12 (14.6)
 Digestive system12 (11.0)4 (14.8)8 (9.8)
 Skin or soft tissue6 (5.5)2 (7.4)4 (4.9)
 Other3 (2.7)1 (3.7)2 (2.4)

Bacteriological categories0.228
 Gram-negative bacteria70 (64.2)16 (59.3)54 (65.9)
 Gram-positive bacteria35 (32.1)9 (33.3)26 (31.7)
 Fungi4 (3.7)2 (7.4)2 (2.4)
 Mechanical ventilation days6.5 ± 7.68.6 ± 10.83.1 ± 5.20.017
 Days in the ICU9.3 ± 12.711.5 ± 16.27.7 ± 8.20.023
 28-day mortality33.0%51.9%26.8%0.016

APACHE: Acute Physiology and Chronic Health Evaluation; SOFA: Sequential Organ Failure Assessment; WBC: white blood cells; PCT: procalcitonin; CRP: C-reactive protein; BUN: blood urea nitrogen; AST: aspartate aminotransferase; ALT: alanine aminotransferase; BNP: B-type natriuretic peptide. .

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