Canadian Journal of Infectious Diseases and Medical Microbiology / 2019 / Article / Tab 2

Research Article

Association between Elevated Serum Tau Protein Level and Sepsis-Associated Encephalopathy in Patients with Severe Sepsis

Table 2

Relative performance of serum tau protein, SOFA score, or a combination of both in predicting SAE in patients with severe sepsis.

AUC (95% CI)Sensitivity (%)Specificity (%)PPV (%)NPV (%)Positive LRNegative LR

Tau protein0.770 (0.671–0.89)70.472.045.388.12.5140.411
SOFA score0.723 (0.615–0.82)66.765.939.285.71.9560.505
Tau protein + SOFA score0.798 (0.705–0.890)81.570.047.392.02.7170.264

AUC, area under the curve; PPV, positive predictive value; NPV, negative predictive value; LR, likelihood ratio; CI, confidence interval; SOFA: Sequential Organ Failure Assessment. The diagnostic cutoff values for serum tau protein and SOFA score were 71.96 pg/mL and 6, respectively.

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