Value of Time to Positivity of Blood Culture in Children with Bloodstream Infections

Table 3

Relationship between TTP and resistant phenotype.

Microorganisms	No.	Average of TTP	Minimum TTP	Maximum TTP	t	Value of P
CoNS
MRCNS	402	36.55 ± 13.58	9.17	92.73	0.077	0.782
MSCNS	98	38.23 ± 13.31	14.07	86.35
S. aureus
MRSA	10	17.37 ± 4.25	12.3	35.1	7.671	0.010
MSSA	19	26.63 ± 8.94	14.1	46.57
S. pneumoniae
PNSP	3	17.91 ± 3.22	14.38	20.7	2.174	0.166
PSSP	11	19.35 ± 8.03	10.43	36.85
Enterobacteriaceae
ESBLs	59	13.77 ± 5.65	3.23	33.85	8.904	0.004
Non-ESBLs	36	19.98 ± 10.82	9.05	60.23
A. baumannii
XDR	5	13.09 ± 4.23	9.48	19.58	11.113	0.009
Non-XDR	6	24.74 ± 13.99	11.42	44.67

TTP: time to positivity; CoNS: coagulase-negative Staphylococcus; MRSA: methicillin-resistant Staphylococcus aureus; MSSA: methicillin-susceptible Staphylococcus aureus; PNSP: penicillin-nonsusceptible S. pneumoniae; PSSP: penicillin-susceptible S. pneumoniae; ESBLs: extended spectrum beta-lactamases; XDR: extensive drug resistance; MRCNS: methicillin-resistant coagulase-negative Staphylococcus; MSCNS: methicillin-susceptible coagulase-negative Staphylococcus.^∗Common resistant phenotypes in some bacteria in clinical process; the TTP of these bacteria could provide earlier detection of drug-resistant isolates, and it would also help clinicians to adjust the antibiotics based on characteristics of smear and TTP after the positivity alarm.