Comparative Evaluation and Measure of Accuracy of ELISAs, CLIAs, and ECLIAs for the Detection of HIV Infection among Blood Donors in China

Table 1

Blood screening laboratories of study participation and their commercially available HIV serology kits.

Code	Blood screening labs	HIV reactive (n = 451)	HIV nonreactive (n = 578)	HIV serology kits
1	SZ	73	50	Bio-Rad HIV Ab-Ag (4^th)	—
2	XY	14	9	InTec HIV Ab	Wantai HIV Ab
3	HB	26	18	Murex HIV Ab-Ag (4^th)	Wantai HIV Ab-Ag (4^th)
4	JS	32	50	InTec HIV Ab	Wantai HIV Ab-Ag (4^th)
5	LN	19	50	KHB HIV Ab	InTec HIV Ab
6	HLJ	29	76	Bio-Rad HIV Ab-Ag (4^th)	InTec HIV Ab
7	SD	44	50	InTec HIV Ab	Murex HIV Ab-Ag (4^th)
8	TJ	70	49	Murex HIV Ab-Ag (4^th)	Wantai HIV Ab-Ag (4^th)
9	HN	25	112	Wantai HIV Ab	-
10	CQ	31	18	Bio-Rad HIV Ab-Ag (4^th)	InTec HIV Ab
11	YN	8	15	Bio-Rad HIV Ab-Ag (4^th)	KHB HIV Ab
12	JL	48	11	KHB HIV Ab	Wantai HIV Ab-Ag (4^th)
13	HZ	3	21	Livzon HIV Ab	—
14	TZ	29	49	Bio-Rad HIV Ab-Ag (4^th)	Murex HIV Ab-Ag (4^th)
15	BJ	—	—	Bio-Rad HIV Ab-Ag (4^th)	Wantai HIV Ab
16	ZH	—	—	Livzon HIV Ab-Ag (4^th)	—
17	JN	—	—	KHB HIV Ab	Wantai HIV Ab-Ag (4^th)
18	CZ	—	—	Murex HIV Ab-Ag (4^th)	—
19	NCCL	—	—	Abbott ARCHITECT HIV Ag/Ab Combo^§ (4^th)	Roche Elecsys HIV combi PT^† (4^th)

a: ^§ CLIA,^† ECLIA, and other HIV serology kits are ELISAs. b: 4^th: fourth-generation ELISA kits. Other HIV serology kits are third-generation ELISA kits. ELISAs: Wantai Diagnostic Kit for antibody to human immunodeficiency virus (Beijing Wantai Biological Pharmacy, Beijing, China) (Wantai), Wantai Diagnostic Kit for antibody and antigen to human immunodeficiency virus (Beijing Wantai Biological Pharmacy, Beijing, China) (Wantai (4^th)), Beijing, China; KHB Diagnostic Kit for antibody to human immunodeficiency virus (Shanghai Kehua Bioengineering Co., Shanghai, China) (KHB), InTec Diagnostic Kit for antibody to human immunodeficiency virus (InTec Products, Inc., Xiamen, China) (InTec), Livzon Diagnostic Kit for antibody to human immunodeficiency virus (Zhuhai Livzon Diagnostics Inc., Zhuhai, China) (Livzon), Livzon Diagnostic Kit for antibody and antigen to human immunodeficiency virus (Zhuhai Livzon Diagnostics Inc., Zhuhai, China) (Livzon (4^th)), Murex HIV Ag/Ab combination (Diasorin, Saluggia, Italy) (Murex (4^th)), Bio-Rad GS HIV Combo Ag/Ab EIA (Bio-Rad, Marnes la Coquette, France) (Bio-Rad (4^th)). c: blood centers (codes 1–14) were sources of study samples. d: blood centers (codes 3–18) performed HIV screening for all the samples using one or two ELISA kits. CLIA and ECLIA were conducted by NCCL.