Comparative Evaluation and Measure of Accuracy of ELISAs, CLIAs, and ECLIAs for the Detection of HIV Infection among Blood Donors in China
Table 2
The NPV and PPV of initial ELISA results for HIV blood screening.
HIV screening
Single ELISA kit (284)
Two different ELISA kits (745)
ELISA (1029)
ECLIA
CLIA
Status
Nonreactive
Reactive
Dual nonreactive
Single reactive
Dual reactive
Nonreactive
Reactive
Sum
Nonreactive
Reactive
Nonreactive
Reactive
183
101
395
200
150
578
451
1029
884
145
885
144
True negatives
183
71
395
198
46
578
315
893
884
9
885
8
True positives
0
30
0
2
104
0
136
136
0
136
0
136
NPV§
100% (183/183)
—
100% (395/395)
—
—
100% (578/578)
—
100% (578/578)
100% (884/884)
—
100% (885/885)
—
PPV§
—
29.7% (30/101)
—
1.0% (2/200)
69.3% (104/150)
—
30.2% (136/451)
30.2% (136/451)
—
93.8% (136/145)
—
94.4% (136/144)
§: positive predictive value (PPV) and negative predictive value (NPV) are the proportions of positive and negative results in statistics and diagnostic tests that are true positive and true negative results, respectively.
