Research Article
Comparative Analysis of 95 Patients with Different Severity in the Early Outbreak of COVID-19 in Wuhan, China
Table 2
Laboratory findings of COVID-19 patients on hospital admission.
| | Laboratory findings | All patients | Disease severity | value | | Common | Severe | Critical |
| | Number | 95 | 54 (56.8) | 27 (28.4) | 14 (14.7) | — | | Blood routine | | | | | | | Leukocyte count, ×10⁹/L | 5.6 (4.5–7.0) | 5.0 (4.3–6.7) | 5.8 (4.9–7.4) | 7.1 (5.5–10.3) | 0.010 | | <4 | 17 (17.9) | 11 (20.4) | 5 (18.5) | 1 (7.1) | 0.513 | | 4–10 | 71 (74.7) | 42 (77.8) | 20 (74.1) | 9 (64.3) | 0.583 | | >10 | 7 (7.4) | 1 (1.9) | 2 (7.4) | 4 (28.6) | 0.003 | | Neutrophil count, ×10⁹/L | 4.0 (2.8–5.1) | 3.6 (2.6–4.4) | 4.5 (3.3–5.8) | 5.0 (4.1–9.3) | 0.002 | | <1.5 | 5 (5.3) | 5 (9.3) | 0 (0) | 0 (0) | 0.135 | | 1.5–7 | 79 (83.2) | 46 (85.2) | 23 (85.2) | 10 (71.4) | 0.446 | | >7 | 11 (11.6) | 3 (5.6) | 4 (14.8) | 4 (28.6) | 0.046 | | Lymphocyte count, ×10⁹/L | 1.0 (0.8–1.4) | 1.1 (0.8–1.6) | 1.0 (0.6–1.3) | 0.9 (0.5–1.2) | 0.137 | | <1.5 | 75 (78.9) | 40 (74.1) | 23 (85.2) | 12 (85.7) | 0.409 | | Platelet count, × 10⁹/L | 168 (126–220) | 166.5 (126–226.3) | 185 (125–227) | 158 (117–206) | 0.780 | | <150 | 36 (37.9) | 20 (37.0) | 9 (33.3) | 7 (50.0) | 0.569 | | Hemoglobin, g/L | 136 (125–147) | 133 (125.8–148) | 137 (118–145) | 140.5 (129–147) | 0.755 | | C-reactive protein, mg/L | 32.6 (7.6–80.1) | 12.9 (3.1–44.3) | 52.6 (27.2–112.6) | 80.1 (22.0–118.5) | ＜0.001 | | >10 | 56 (58.9) | 26 (48.1) | 21 (77.8) | 9 (64.3) | 0.035 | | Blood biochemistry | | | | | | | Aspartate aminotransferase, U/L | 34.4 (22.8–46.0) | 29.2 (19.7–40.6) | 37.7 (27.5–46.0) | 41.2 (19.3–60.7) | 0.108 | | >40 | 32 (33.7) | 14 (25.9) | 10 (37.0) | 8 (57.1) | 0.080 | | Alanine aminotransferase, U/L | 27.6 (17.8–42.2) | 24.5 (13.2–36.1) | 30.0 (18.4–45.0) | 35.2 (24.4–46.0) | 0.172 | | >40 | 25 (26.3) | 11 (20.4) | 9 (33.3) | 5 (35.7) | 0.315 | | Urea nitrogen, mmol/L | 4.0 (2.8–5.1) | 3.5 (2.7–4.5) | 5.1 (3.1–9.1) | 4.4 (3.6–6.5) | 0.004 | | >7.5 | 15 (15.8) | 3 (5.6) | 9 (33.3) | 3 (21.4) | 0.004 | | Creatinine, umol/L | 65.8 (51.6–81.8) | 63.5 (49.3–77.0) | 72.1 (54.0–105.0) | 67.4 (59.4–80.3) | 0.011 | | >133 | 3 (3.2) | 0 (0) | 3 (11.1) | 0 (0) | 0.020 | | LDH, U/L | 264.4 (192.1–372.2) | 245.3 (179.6–329.7) | 301.3 (199.8–402.9) | 388.0 (311.4–561.4) | 0.010 | | Creatine kinase, U/L | 56.9 (41.1–98.7) | 52.0 (36.5–89.8) | 56.2 (46.9–136.6) | 73.8 (50.9–359.2) | 0.210 | | Albumin, g/L | 35.8 (32.0–39.6) | 37.2 (34.4–39.8) | 34.8 (30.3–39.6) | 29.6 (28.1–33.8) | ＜0.001 | | Potassium, mmol/L | 3.7 (3.3–4.0) | 3.6 (3.4–3.9) | 3.8 (3.3–4.2) | 3.6 (3.0–3.9) | 0.201 | | Calcium, mmol/L | 2.2 (2.2–2.3) | 2.3 (2.2–2.4) | 2.2 (2.1–2.3) | 2.2 (2.1–2.3) | 0.039 | | Coagulation function | | | | | | | Prothrombin time, s | 12.9 (12.2–13.5) | 12.6 (12.1–13.1) | 13.8 (12.1–14.3) | 13.4 (12.7–14.2) | 0.002 | | >13.5 | 23 (24.2) | 4 (7.4) | 15 (55.6) | 4 (28.6) | ＜0.001 | | D-dimer, mg/L | 0.71 (0.36–3.39) | 0.51 (0.31–0.84) | 1.90 (0.68–23.81) | 2.60 (0.59–21.46) | ＜0.001 | | >0.5 | 60 (63.2) | 26 (48.1) | 22 (81.5) | 12 (85.7) | 0.002 | | First nucleic acid test | | | | | 0.323 | | Positive | 62 (65.3) | 32 (59.3) | 19 (70.4) | 11 (78.6) | — | | Negative | 33 (34.7) | 22 (40.7) | 8 (29.6) | 3 (21.4) | — |
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Data are presented as n (%) or medians (interquartile ranges, IQR). LDH, lactate dehydrogenase.
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