Frequent Recurrences of Genital Herpes Are Associated with Enhanced Systemic HSV-Specific T Cell Response

Figure 1

The comparison of HSV-1 and HSV-2-specific interferon-γ production measured by Elispot in patients with genital herpes and HSV-2 seronegative healthy controls (C). Patient groups: group 1 (G1), patients with <10 genital herpes recurrences per a year; group 2 (G2), patients with >10 genital herpes recurrences per a year. Interferon-γ production is reported as spot-forming cells (SFC)/10⁶ peripheral blood mononuclear cells (PBMC). The 25th and 75th percentiles define boxes, and the median values are indicated. The Kruskal–Wallis test was used to detect significant differences among the groups indicated above the boxes versus controls; , .