Frequent Recurrences of Genital Herpes Are Associated with Enhanced Systemic HSV-Specific T Cell Response
Table 1
Demographic, clinical, and laboratory data of patients with genital herpes and HSV-2 seronegative healthy controls.
Parameter
Group 1 (n = 7)
Group 2 (n = 19)
Controls (n = 12)
Sex (male/female)
0/7
7/12
4/8
Age (mean, range)
48.7, 21–73
39.2, 27–60
35.8, 26–61
Recurrences (mean, range)
3.3, 2–6
13.3, 10–24
—
Detection of HSV DNA in genital swab (+/0)
4/3
14/5
—
Presence of anti-HSV-2 IgG (+/−)
7/0
17/2
0/12
Presence of anti-HSV-1 IgG (+/−)
5/2
12/7
8/4
Suppressive therapy (valaciclovir)
1
6
—
Episodicall treatment (valaciclovir or acyclovir)
4
13
—
Without treatment
2
—
12
Group 1, patients with low frequency of GH recurrences (<10 recurrences/year); Group 2, patients high frequency of GH recurrences (>10 recurrences/year); +, positive; −, negative.
