Coinfection of High-Risk Human Papillomavirus and Lower Genital Tract Pathogens in the Development of High-Grade Cervical Lesions
Table 2
Rates of HR-HPV and other pathogens coinfections and risk of the coinfections in high-grade cervical lesions.
Coinfection status
Overall
≤LSIL
≥HSIL
valuea
valueb
OR (95% CI)
ORadjust (95% CI)
adjust
HR-HPV (+)
PB (−)
297
113 (38.0)
184 (62.0)
0.001
0.001
1
1
0.001
PB (+)
163
35 (21.5)
128 (78.5)
2.246 (1.445–3.491)
2.250 (1.423–3.557)
HR-HPV (−)
PB (−)
355
337 (94.9)
18 (5.1)
0.024
1
1
0.023
PB (+)
67
58 (86.6)
9 (13.4)
2.905 (1.245–6.779)
2.779 (1.154–6.689)
HR-HPV (+)
UU (−)
335
118 (35.2)
217 (65.8)
0.022
0.001
1
1
0.020
UU (+)
125
30 (24.0)
95 (76.0)
1.722 (1.079–2.749)
1.791 (1.096–2.926)
HR-HPV (−)
UU (−)
386
365 (94.6)
21 (5.4)
0.020
1
1
0.021
UU (+)
36
30 (83.3)
6 (6.7)
3.476 (1.304–9.269)
4.163 (1.243–13.941)
HR-HPV (+)
MH (−)
429
143 (14.5)
286 (85.5)
0.048
0.829
1
1
0.202
MH (+)
31
5 (35.7)
26 (64.3)
2.600 (0.978–6.913)
1.930 (0.703–5.298)
HR-HPV (−)
MH (−)
392
368 (93.9)
24 (6.1)
0.427
1
1
0.461
MH (+)
30
27 (90.0)
3 (10.0)
1.704 (0.482–6.020)
0.551 (0.113–2.683)
HR-HPV (+)
CT (−)
384
137 (35.7)
247 (64.3)
0.001
0.001
1
1
0.001
CT (+)
76
11 (14.5)
65 (85.5)
3.278 (1.673–6.419)
3.070 (1.540–6.120)
HR-HPV (−)
CT (−)
404
380 (94.1)
24 (5.9)
0.100
1
1
0.096
CT (+)
18
15 (83.3)
3 (6.7)
3.167 (0.857–11.694)
3.190 (0.815–12.494)
Values are presented as number (%). aCompared in different lower genital tract pathogens infection states. bCompared in different HR-HPV infection states. adjust: after adjustment for age and menopausal status. P < 0.05. ≤LSIL: normal or low-grade squamous intraepithelial lesion; ≥HSIL: high-grade squamous intraepithelial lesion or cervical squamous cell carcinoma; HR-HPV: high-risk human papillomavirus; OR: odds ratio.
