Association of the rs562556 PCSK9 Gene Polymorphism with Reduced Mortality in Severe Malaria among Malian Children
Table 1
Association of clinical symptoms with death and survival.
Symptoms
Death/survival
Died (N = 16)
Survived (N = 191)
n
(%)
n
(%)
Convulsion
13
(81.3)
99
(51.8)
0.0343
Seizure
8
(50.0)
73
(38.2)
0.4265
Prostration
5
(31.5)
20
(10.5)
0.0296
Lethargy
10
(62.5)
41
(21.5)
0.0074
Coma
8
(50.0)
37
(19.4)
0.0089
Resp. symptoms
10
(62.5)
90
(47.1)
0.3007
Respiratory distress
7
(43.8)
3
(1.6)
<0.0001
Abdominal pain
2
(12.5)
37
19.4)
0.7417
Vomit
10
(62.5)
96
(50.3
0.4383
Repeated vomit
5
(31.3)
11
(5.8)
0.0038
Diarrhea
7
(43.8)
56
(29.3)
0.2613
No food
4
(25.0)
19
(9.9)
0.0851
Hypoglycemiab
2
(12.5)
2
(1.0)
0.0308
Severe anemiac
7
(43.8)
21
(11.0)
0.0019
Dark urine
3
(18.8)
14
(7.3)
1.0000
Jaundice
1
(6.2)
12
(6.3)
1.0000
Dysurea
1
(6.2)
5
(2.6)
0.3867
Hyperparasitemiad
2
(12.5)
100
(52.5)
0.0030
aP by Fisher’s exact test. Significance was set at 0.05. Significant values are bolded. bGlucose ≤40 mg/dL; chemoglobin ≤5 g/dL; dparasitemia ≥500 000/μL.
