Determination of Voriconazole Plasma Concentration by HPLC Technique and Evaluating Its Association with Clinical Outcome and Adverse Effects in Patients with Invasive Aspergillosis

Table 1

Patients’ demographic characteristics and clinical data.

Characteristics	Number (%)
Male sex	12 (54.54)
Age	Median: 57 years (range: 21–69 years)
Weight	Median: 61 kg (range: 36–90 kg)
BMI	Median: 21.61 kg/m^2 (range: 14.98–37.45 kg/m^2)
Infection
Proven	12 (54.54)
Probable	9 (40.91)
Possible	1 (4.55)
Underlying diseases
DM	2 (9.09)
HTN	5 (22.73)
COPD	4 (18.18)
CVA	1 (4.55)
CKD	3 (13.64)
Chronic steroid use	6 (27.27)
Hypothyroidism	3 (13.64)
Route of administration
Oral	17 (77.27)
IV	3 (13.64)
IV to oral	2 (9.09)

DM, diabetes mellitus; HTN, hypertension; COPD, chronic obstructive pulmonary disease; CVA, cerebrovascular accident; CKD, chronic kidney disease.