Determination of Voriconazole Plasma Concentration by HPLC Technique and Evaluating Its Association with Clinical Outcome and Adverse Effects in Patients with Invasive Aspergillosis

Table 2

Frequency of adverse reactions according to voriconazole plasma levels.

Adverse reactions	VRZ levels			Total	value
	Subtherapeutic	Therapeutic	Supratherapeutic
Skin rash	0	1	2	3	0.129
Tachycardia	0	0	1	1	0.168
Fever	0	2	3	5	0.054
Nausea and vomiting	1	0	2	3	0.094