Cytotoxin-Associated Gene A-Positive Helicobacter pylori Promotes Autophagy in Colon Cancer Cells by Inhibiting miR-125b-5p

Figure 2

CagA overexpression inhibits miR-125b-5p, while miR-125b-5p does not affect CagA expression in DLD-1 and SW620 colon cancer cells. (a) and (c) represent the transfection of CagA plasmid decreased the miR-125b-5p level, while transfection of miR-125b-5p did not affect the CagA mRNA level in DLD-1 (a) and SW620 (c) cancer cell lines. (b) and (d) represent the transfection of miR-125b-5p did not affect the CagA protein level in DLD-1 (b) and SW620 (d) cancer cell lines. , compared with mimic-NC + OE-NC, and , compared with mimic-NC + OE-CagA group.

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