Chronic Hepatitis C Virus Infection Modulates the Transcriptional Profiles of CD4⁺ T Cells

Table 2

Comparison of the expression levels of transcriptional factors and the percentage of myeloid-derived suppressor cells among the study groups.

Parameters	CHC	SC	HC
T-bet^+ CD4^+ T cells (%)	15.95 (15.54)	12.3 (12.86)	14.9 (15.86)
Gata3^+ CD4^+ T cells (%)	56.05 (42.78)	68.6 (18.35)	65.4 (14.7)
Rorγt^+ CD4^+ T cells (%)	83.30 (34.33)	96.6 (1.8)	93.6 (10.7)
Foxp3^+ CD4^+ T cells (%)	5.33 (1.9)	4.75 (1.08)	4.38 (1.16)
T-bet/Gata3	0.293 (0.444)	0.170 (0.181)	0.182 (0.254)
Foxp3/Rorγt	0.077 (0.072)	0.049 (0.009)	0.048 (0.015)
MDSC (%)	0.86 (0.8)	0.66 (0.77)	0.91 (0.99)

Data are in medians (IQR); CHC, chronic hepatitis C; SC, spontaneous viral clearance; HC, healthy controls; vs. patients; vs. patients; MDSC, myeloid-derived suppressor cells.