Chronic Hepatitis C Virus Infection Modulates the Transcriptional Profiles of CD4+ T Cells
Table 2
Comparison of the expression levels of transcriptional factors and the percentage of myeloid-derived suppressor cells among the study groups.
Parameters
CHC
SC
HC
T-bet+ CD4+ T cells (%)
15.95 (15.54)
12.3 (12.86)
14.9 (15.86)
Gata3+ CD4+ T cells (%)
56.05 (42.78)
68.6 (18.35)
65.4 (14.7)
Rorγt+ CD4+ T cells (%)
83.30 (34.33)
96.6 (1.8)
93.6 (10.7)
Foxp3+ CD4+ T cells (%)
5.33 (1.9)
4.75 (1.08)
4.38 (1.16)
T-bet/Gata3
0.293 (0.444)
0.170 (0.181)
0.182 (0.254)
Foxp3/Rorγt
0.077 (0.072)
0.049 (0.009)
0.048 (0.015)
MDSC (%)
0.86 (0.8)
0.66 (0.77)
0.91 (0.99)
Data are in medians (IQR); CHC, chronic hepatitis C; SC, spontaneous viral clearance; HC, healthy controls; vs. patients; vs. patients; MDSC, myeloid-derived suppressor cells.