Effect of Antifungal-Treated Host Macrophages on Candida glabrata

Figure 1

SOD activity of C. glabrata in macrophages pretreated with three antifungal drugs. We measured the SOD activity of macrophages treated with MCF, ICZ, and AmB. The control group was not pretreated with antifungal agents. The SOD level after 1 hour was significantly increased compared with the SOD level of nonphagocytized C. glabrata (0 hour) (^∗, ). The mean SOD level of fungus-infected macrophages treated with MCF was lower than that of untreated fungus-infected macrophages, especially 6–12 hours after infection (^∗∗, ). There was no significant difference in SOD levels between the untreated and ICZ- or AmB-treated fungus-infected macrophage groups (^∗∗∗, ).