Evaluation of Intraventricular/Intrathecal Antimicrobial Therapy in the Treatment of Nosocomial Meningitis Caused by Multidrug-Resistant Gram-Negative Bacteria after Central Nervous System Surgery

Table 1

Demographic data, operation indications, microbiological agent, empirical and agent targeted antibiotic preferences, and durations of therapies.

Case	Age/gender	Operation indication	Days of POM development	Empirical therapy	Microbiological agent	Agent targeted therapy (IV)	Duration (days)	IV/IVT therapy	Duration (days)	Last status
1	52/M	Intraventricular hemorrhage	12	Mem, Va	A. baumanni	Mem, Col	5	Col	5	Exitus
2	56/M	Hydrocephalus	1	Caz, Va	A. baumanni	Tig, Col	21	Col	10	Cure
3	54/M	Aneurysm	11	Caz, Va	A. baumanni	Mem, Col	5	Col	5	Exitus
4	54/M	Hydrocephalus	34	Caz, Va	K. pneumoniae	Mem, Ak	15	Ak	10	Cure
5	39/F	Aneurysm	9	Mem, Va	A. baumanni	Mem, Col	7	Col	7	Exitus
6	42/M	Aneurysm	15	Caz, Va	A. baumanni	Mem, Col	12	Col	7	Exitus
7	16/M	Aneurysm	7	Mem, Va	A. baumanni	Tig, Col	20	Col	14	Cure
8	49/M	Aneurysm	10	Caz, Va	A. baumanni	Tig, Va, Col	20	Col	14	Cure
9	71/M	Aneurysm	42	Caz, Va	A. baumanni	Mem, Col	14	Col	10	Cure
10	16/M	Shunt revision	2	Mem, Va	K. pneumoniae	Mem, Ak	13	Ak	10	Exitus
11	42/F	Trauma	6	Cro, Va	A. baumanni	Mem, Col	12	Col	10	Exitus
12	52/M	Aneurysm	12	Mem, Va	A. baumanni	Mem, Col	10	Col	10	Exitus
13	75/M	Trauma	2	Mem, Va	K. pneumoniae	Mem, Va	21	Ak	10	Cure
14	58/F	Aneurysm	6	Mem, Va	K. pneumoniae	Mem, Ak	7	Ak	7	Exitus

IV: intravenous; IVT: intraventricular; Mem: meropenem; Va: vancomycin; Caz: ceftazidime; Cro: ceftriaxone; Tig: tigecycline; Col: colistimethate sodium; Ak: amikacin.