Risk Factors and Outcome of Sepsis in Traumatic Patients and Pathogen Detection Using Metagenomic Next-Generation Sequencing
Table 2
Patient characteristics between sepsis and non-sepsis groups.
Characteristic
Sepsis (n = 142)
Non-sepsis (n = 386)
P
Age (year)
50.18 ± 13.68
48.93 ± 14.34
0.369
Gender (male/%)
105 (73.94%)
281 (72.80%)
0.792
BMI
25.22 ± 3.60
24.70 ± 2.84
0.084
Cause of trauma (n/%)
0.093
Traffic-related injury
65 (45.77%)
190 (49.22%)
Falling injury
54 (38.03)
163 (42.23%)
Blunt-force injury
14 (9.86%)
20 (5.18%)
Other
9 (6.34%)
13 (3.37%)
Location of trauma
>0.05
Head and neck
74 (45.68%)
190 (49.22%)
Limbs and pelvis
79 (55.63%)
178 (46.11%)
Chest
97 (68.31%)
236 (61.14%)
Abdomen
26 (18.31%)
59 (15.28%)
Previous medical history (n/%)
22 (15.49%)
40 (10.36%)
0.104
Time of admission (h)
10.39 ± 5.33
10.08 ± 5.26
0.550
Shock on admission (n/%)
63
104
<0.001
Operation within 24 h after EICU admission (n/%)
110 (77.46%)
281 (72.80%)
0.278
Blood transfusion (n/%)
126 (88.73%)
281 (72.80%)
<0.001
Mechanical ventilation (n/%)
129 (90.85%)
300 (77.72%)
<0.001
Body temperature (°C)
37.59 ± 0.62
37.37 ± 0.42
<0.001
Heart rate (/min)
103.81 ± 17.09
92.00 ± 17.03
<0.001
SBP (mmHg)
122.47 ± 13.42
121.44 ± 13.48
0.143
DBP (mmHg)
68.63 ± 8.92
70.07 ± 8.22
0.082
Blood pH
7.39 ± 0.11
7.40 ± 0.09
0.288
Oxygenation index (mmHg)
314.14 ± 190.34
335.70 ± 198.59
0.264
SpO2 (%)
87.57 ± 12.6
88.22 ± 11.71
0.580
PaO2 (mmHg)
140.93 ± 65.82
139.1 ± 66.14
0.778
PaCO2 (mmHg)
37.11 ± 9.24
35.86 ± 6.22
0.076
WBC count (1 × 109/L)
13.45 ± 4.84
11.43 ± 5.73
<0.001
Neutrophil count (1 × 109/L)
14.21 ± 7.07
12.43 ± 6.5
0.007
Hematocrit (%)
31.49 ± 12.12
35.77 ± 14.95
0.002
Platelet count (1 × 109/L)
165.59 ± 87.09
157.89 ± 71.22
0.301
TBA (μmol/L)
18.14 ± 1.89
17.99 ± 2.24
0.478
Albumin (g/L)
33.26 ± 8.14
32.09 ± 7.28
0.114
TBIL (mg/dL)
20.48 ± 2.17
20.29 ± 1.94
0.335
Urea nitrogen (mmol/L)
7.35 ± 4.3
5.85 ± 2.06
<0.001
Creatinine (μmol/L)
91.09 ± 47.85
73.41 ± 22.62
<0.001
CRP (mg/dL)
12.1 ± 0.78
7.10 ± 0.66
<0.001
D-D dimer (mg/L)
3.26 ± 1.27
1.22 ± 0.42
<0.001
PCT (mg/L)
4.03 ± 1.29
1.32 ± 0.18
<0.001
Lactic acid (mmol/L)
5.32 ± 1.72
5.09 ± 1.6
0.152
Blood glucose (mmol/L)
8.85 ± 3.32
8.4 ± 2.62
0.105
APACHE II score
51.52 ± 7.11
43.71 ± 6.32
<0.001
SOFA score
7.77 ± 2.13
5.36 ± 2.37
<0.001
ISS score
24.73 ± 4.92
20.43 ± 3.97
<0.001
MODS
102 (71.83%)
148 (38.24%)
<0.001
Respiratory dysfunction
115 (80.99%)
203 (52.59%)
<0.001
Coagulation disorder
66 (46.48%)
146 (37.82%)
0.072
Neurological dysfunction
55 (38.73%)
124 (32.12%)
0.155
Circulating dysfunction
51 (35.92%)
39 (10.10%)
<0.001
Urinary dysfunction
34 (23.94%)
19 (4.92%)
<0.001
SpO2, oxygen saturation of blood; PtO2, oxygen partial pressure; PtCO2, carbon dioxide partial pressure; Hb, hemoglobin; TBA, total bile acid; TBIL, total bilirubin; CRP, C-reactive protein; PCT, procalcitonin; APACHE II, acute physiology and chronic health evaluation II; SOFA, sequential organ failure assessment; ISS, Injury Severity Score; MODS, Multiple Organ Dysfunction Syndromes. The measurement data which are normally distributed are shown as mean ± standard deviation and compared by student's t-test. The enumeration data are presented as percentage and compared using chi-square test.
