Effects of Bedaquiline on Antimicrobial Activity and Cytokine Secretion of Macrophages Infected with Multidrug-Resistant Mycobacterium tuberculosis Strains

Table 6

Levels of IL-10 in culture supernatants of macrophages infected with H37Rv and MDR-MTB strains after Bdq administration (pg/ml, ).

	4 h before administration	4 h after administration	24 h after administration	48 h after administration	F test	value
H37Rv strains
Control	465.43 ± 5.95	528.99 ± 1.70	582.81 ± 3.58	566.52 ± 0.25	425.322	0.001
Bdq	465.43 ± 5.95	483.38 ± 43.61	431.66 ± 87.93	440.30 ± 25.79	0.432	0.742
t-test	—	1.478	2.429	6.921	—	—
value	—	0.277	0.136	0.020	—	—
MDR-MTB strains
Control	525.71 ± 79.17	544.22 ± 0.80	571.63 ± 1.93	627.78 ± 4.40	2.517	0.197
Bdq	525.71 ± 79.17	470.29 ± 32.51	471.07 ± 15.67	466.71 ± 16.06	0.815	0.549
t-test	—	3.215	9.005	13.680	—	—
value	—	0.085	0.012	0.005	—	—