Canadian Journal of Infectious Diseases and Medical Microbiology

Research Article

Hsa_circ_0000479/Hsa-miR-149-5p/RIG-I, IL-6 Axis: A Potential Novel Pathway to Regulate Immune Response against COVID-19

Table 4

The expression levels of hsa_circ_0000479, hsa-miR-149-5p, IL-6, and RIG-I in negative controls, nonsymptomatic COVID-19, and symptomatic COVID-19 patients (values 1: in comparison with negative control, 2: in comparison with nonsymptomatic COVID-19).


Gene name	Group	N	Mean	SD	Median	-value1	-value2

hsa_circ_0000479	Negative control	50	8.073	22.661	1.238
	Nonsymptomatic COVID-19	50	19.903	25.199	8.681	0.003
	Symptomatic COVID-19	50	58.625	81.253	20.608	<0.001	0.012

hsa-miR-149-5p	Negative control	50	2.123	2.600	1.088
	Nonsymptomatic COVID-19	50	0.207	0.296	0.038	<0.001
	Symptomatic COVID-19	50	0.179	0.395	0.023	<0.001	0.163

RIG-I	Negative control	50	4.463	7.289	1.091
	Nonsymptomatic COVID-19	50	48.413	66.450	22.013	<0.001
	Symptomatic COVID-19	50	121.275	113.371	88.392	<0.001	0.090

IL-6	Negative control	50	12.744	22.678	1.266
	Nonsymptomatic COVID-19	50	65.659	78.441	24.345	<0.001
	Symptomatic COVID-19	50	136.516	117.751	120.641	<0.001	0.005