Enzymatic Activity and Horizontal Gene Transfer of Heavy Metals and Antibiotic Resistant Proteus vulgaris from Hospital Wastewater: An Insight

Table 11

ADME/Tox prediction of the different used drugs.

S. no.	Compounds	CaCO2	HIA	MDCK	PPB	SP	Toxicity (M/Cm,Cr)
1.	Amoxicillin	0.3483	62.936	0.3985	23.3530	−5.149	+/−, −
2.	Chloramphenicol	17.5665	83.2759	1.3436	65.9271	−4.053	+/−,−
3.	Erythromycin	23.3211	52.9870	0.04341	36.0565	−2.859	−/−, −
4.	Gentamycin	4.4695	5.2795	0.46653	46.930	−5.184	+/−, −
5.	Methicillin	14.9867	87.322	2.4672	56.0535	−4.704	+/−, −
6.	Nalidixic acid	0.276663	96.2385	30.345	76.8196	−3.888	+/+, −
7.	Neomycin	1.7782	0	0.5092	43.566	−5.305	+/−, −
8.	Penicillin	11.859	92.7501	3.13642	82.5857	−4.546	-/-, -
9.	Ciprofloxacin	21.280	96.270	10.302	31.053	−4.597	+/−, −
10.	Kanamycin	2.015	0.13581	0.5170	42.225	−5.279	+/−, −
11.	Nitrofurazole	20.107	74.332	37.430	0	−2.944	+/−, −
12.	Ofloxacin	25.943	98.3543	13.764	28.788	−4.629	+/−, −
13.	Polymyxin B	20.4008	0	0.0434	44.899	−2.290	+/+, −
14.	Tetracycline	19.274	35.2166	0.50796	33.2060	−4.672	−/−, −
15.	Ampicillin	0.6307	81.4784	0.93758	36.154	−5.035	+/−, −

CaCO2 = Caco2 cell permeability, HIA = human intestinal absorption, MDCK = Madin-Darby canine kidney, PPB = plasma protein binding, SP = skin permeability.