Research Article

Diagnostic Value of Metagenomic Next-Generation Sequencing for Pneumonia in Immunocompromised Patients

Table 1

Patient characteristics and baseline of two groups.

CharacteristicsAll patients (n = 53)Immunocompetent patients (n = 21)Immunocompromised patients (n = 32) value

Age (yr)61 (48.5, 69.5)60 (43.5, 68.5)62.5 (54.8, 70)0.339
Male, n (%)32 (60.4%)13 (61.9%)19 (59.4%)0.854
Hospital length of stay17 (7, 38)8 (6, 33.5)26.5 (12.3, 42.3)0.043
Tobacco use20 (37.7%)6 (28.6%)14 (43.8%)0.265
Alcohol abuse18 (34.0%)5 (23.8%)13 (40.6%)0.206
Oxygenation Index337.4 (173.9, 427.7)355.7 (176.5, 430.4)291.6 (165.0, 434.9)0.821
Mechanical ventilation, n (%)14 (26.4%)2 (9.5%)9 (28.1%)0.167
Lac (mmol/l)1.4 (0.9, 2)1.4 (1.0, 2.1)1.3 (0.9, 2.2)0.657
PCT (ng/ml)0.2 (0.1, 1)0.2 (0.1, 1.3)0.3 (0.1, 1.0)0.796
ESR (mm/h)52 (23.5, 72.5)41 (18, 62.3)53 (26, 78)0.343
HsCRP (mg/l)42.3 (8.5, 96.5)27.6 (2.5, 105.5)45.7 (16.6, 96.5)0.227
WBC (109/L)6.9 (4.4, 9.2)5.8 (4.4, 8.9)7.2 (4.25, 9.7)0.530
Hb (g/L)102 (87.5, 124.5)114 (94.5, 129)100.5 (84.5, 115.8)0.096
LY (109/L)0.6 (0.4, 1.25)1.1 (0.5, 1.4)0.5 (0.3, 1.05)0.044
PLT (109/L)185 (92, 250)191 (145, 230)151 (83.5, 265.3)0.592
Scr (mmol/L)72.3 (60.3, 165.7)64 (55.1, 74.7)89.8 (68.6, 207.8)0.007
ALT (IU/L)19.5 (13, 51)20.5 (11.3, 64)18.5 (13.3, 44.5)0.955
AST (IU/L)22 (18, 49.5)24.5 (18, 76.8)22 (18.3, 40.5)0.658
Alb (g/L)31.2 (27.2, 36.1)31.9 (26.6, 39.2)31.2 (27.5, 35.5)0.721
LDH (IU/L)292 (178.5, 476)192 (151, 431.5)314.5 (200.3, 496.8)0.081
CD3+ Tcell count (/μl)416.4 (256, 845.5)545 (303, 813.7)396.8 (182.3, 960.6)0.549
CD4+T cell count (/μl)225.2 (105, 534)302.9 (171.7, 458.6)164.4 (104.9, 596.1)0.621
CD8+ T cell count (/μl)178.2 (109.6, 331.5)205.2 (124.5, 325.9)175.3 (79.6, 331.5)0.658
CD16 + 56 + cell count (/μl)68.7 (20.9, 146.7)83.8 (28.1, 154.6)68.5 (18.4, 146.7)0.696
B cell count (/μl)77.9 (13.6, 135.9)107.1 (75.9, 402.5)33.1 (11.3, 118.4)0.029

Abbreviations: PCT, procalcitonin; ESR, erythrocyte sedimentation rate; HsCRP, hypersensitivity-C reaction protein; Lac, lactic acid; WBC, white blood cell; Hb, hemoglobin; LY, lymphocyte count; PLT, platelet count; sCr, Serum creatinine; ALT, alanine aminotransferase; AST, aspartate aminotransferase; Alb, albumin; LDH, lactate dehydrogenase. was considered statistically significant.