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| Measure | Reference range | Illness day 4 hospital day 1 | Illness day 9 hospital day 6 | Illness day 10 hospital day 7 | Illness day 12 hospital day 9 | Illness day 15 hospital day 12 | Illness day 16 hospital day 13 | Illness day 17 hospital day 14 | Illness day 20 hospital day 17 | Illness day 21 hospital day 18 |
|
| Complete blood count |
| White-cell count (×109/L) | 3.5–9.5 | 4.07 | 4.16 | 3.6 | 5.39 | 13.21§ | 12.06§ | 13.98§ | 14.00§ | |
| Absolute neutrophil count (×109/L) | 1.8–6.3 | 3.25 | 3.38 | 3.21 | 4.86 | 12.28§ | 11.50§ | 13.47§ | 13.52§ | |
| Absolute lymphocyte count (×109/L) | 1.1–3.2 | 0.56‡ | 0.56‡ | 0.29‡ | 0.35‡ | 0.33‡ | 0.26‡ | 0.24‡ | 0.18‡ | |
| Absolute monocyte count (×109/L) | 0.1–0.6 | 0.25 | 0.22 | 0.10 | 0.17 | 0.56 | 0.25 | 0.19 | 0.19 | |
| Red-cell count (×1012/L) | 3.8–5.1 | 5.19 | 4.59 | 4.59 | 4.75 | 5.01 | 4.84 | 4.87 | 4.10 | |
| Hemoglobin (g/L) | 115–150 | 153 | 140 | 136 | 142 | 149 | 144 | 146 | 124 | |
| Platelet count (×109/L) | 125–350 | 107 | 93‡ | 104‡ | 131 | 181 | 121 | 100 | 71‡ | |
|
| Biochemical test |
| Total protein (g/L) | 65–85 | | | 53.62 | 60.04 | 61.65 | 59.19 | 56.89 | 48.52 | |
| Albumin (g/L) | 35–55 | | | 28.76‡ | 30.25‡ | 26.70‡ | 25.54‡ | 23.22‡ | 25.90‡ | |
| Globulin (g/L) | 20–40 | | | 24.86 | 29.79 | 34.95 | 33.65 | 33.67 | 22.62 | |
| Alanine aminotransferase (ALT) (U/L) | 7–45 | | | 20.92 | 34.97 | 59.99§ | 54.47§ | 46.85§ | 20.07 | |
| Glutamyl transpeptidase (GGT) (U/L) | 5–50 | | | 142.33§ | 165.87§ | 198.86§ | 199.83§ | 186§ | 126.28§ | |
| Lactate dehydrogenase (LDH) (U/L) | 140–271 | | | 331.83§ | 424.24§ | 486.32§ | 541.48§ | 619.78§ | 749.45§ | |
| Urea (mmol/L) | 2.8–7.2 | | | 6.22 | 9.77§ | 8.91§ | 9.17§ | 10.37§ | 15.18§ | |
| Creatinine (umol/L) | 49–90 | | | 74.34 | 84.02 | 83.72 | 86.00 | 77.28 | 77.28 | |
| Sodium (mmol/L) | 137–147 | | | 131.60‡ | 134.60‡ | 137.70 | 137.10 | 136.60‡ | 142.70 | |
| Potassium (mmol/L) | 3.5–5.3 | | | 4.00 | 3.76 | 3.91 | 4.07 | 4.12 | 4.03 | |
| Chloride (mmol/L) | 96–108 | | | 96.20 | 98.70 | 102.90 | 102.70 | 100.30 | 107.60 | |
|
| Arterial blood gas (ABG) analysis |
| Fracture of inspired oxygen (FiO2) | | | | 33% | 85% | 85% | 85% | 85% | 85% | 100% |
| Potential of hydrogen (PH) | 7.35–7.45 | | | 7.457§ | 7.452§ | 7.498§ | 7.478§ | 7.512§ | 7.474§ | 7.429 |
| Pressure of oxygen in arterial blood (mmHg) | 90–100 | | | 53‡ | 73‡ | 55‡ | 61‡ | 87‡ | 49‡ | 27‡ |
| Pressure of carbon dioxide in arterial blood (mmHg) | 35–45 | | | 31.3‡ | 30.7‡ | 30.6‡ | 29.6‡ | 32.4‡ | 36.6 | 42.1 |
| Base excess (mmol/L) | −3.0-3.0 | | | −2.0 | −1.0 | 1.0 | 0.0 | 4.0§ | 3.0 | 3.0 |
| HCO3 (mmol/L) | 22–27 | | | 22.1 | 22.0 | 23.8 | 21.9 | 25.9 | 26.9 | 29.0§ |
|
| Coagulation profile |
| Prothrombin time (sec) | 10.2–14.3 | | | 11.7 | | 12.5 | | 15.8 | 21.4 | |
| International normalized ratio | 0.8–1.2 | | | 1.06 | | 1.16 | | 1.65 | 1.98 | |
| Fibrinogen C (mg/dL) | 2.0–4.0 | | | 409 | | 230 | | 154 | 102 | |
| D-dimer (ng/mL) | 0–0.5 | | | 250 | | | 12397 | 15216 | | |
| CRP (mg/dL) | 0–0.5 | 1.94 | | | 25.32§ | | 17.69§ | 11.52§ | | |
| Procalcitonin (ng/mL) | 0.00–0.05 | | | 0.216§ | 0.226§ | 0.117§ | 0.176§ | 0.188§ | 3.680§ | |
| Interleukin-6 (pg/mL) | 0–7 | | | 17.88§ | 7.34§ | 12.84§ | 24.4§ | 648.5§ | 2932§ | |
| Blood culture | | | | | | Negative | | | | |
| Hepatitis B surface antigen (HBsAg) | 0–1 | | | | | 0.429 | | | | |
| Hepatitis C virus (HCV) antibody | 0–1 | | | | | 0.039 | | | | |
| Human immunodeficiency virus (HIV) antibody | 0–1 | | | | | 0.20 | | | | |
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