| Types of molecule | Proteins and peptides | Mass (kDa) | Function/specificity | Localization |
| Larger granules | Coagulation factors | | | | Factor C | 123 | Serine protease | L-granule | Factor B | 64 | Serine protease | L-granule | Factor G | 110 | Serine protease | L-granule | Proclotting enzyme | 54 | Serine protease | L-granule | Coagulogen | 20 | Gelation | L-granule | Protease inhibitors | | | | LICI-1 | 48 | Serpin/factor C | L-granule | LICI-2 | 42 | Serine clotting enzyme | L-granule | | | Serine/factor G | | LICI-3 | 53 | Complement | L-granule | α2-Macroglobulin | 180 | GNB | Plasma, L-granule | Anti-LPS factor | 12 | GNB | L-granule | Factor D | 42 | GNB | L-granule | Lectins | | | | Tachylectin-1 | 27 | LPS (KDO), LTA | L-granule | Tachylectin-2 | 27 | GlcNAc, LTA | L-granule | Tachylectin-3 | 15 | LPS (O-antigen) | L-granule | Tachylectin-4 | 470 | LPS (O-antigen), LTA | L-granule | Tachylectin-5A | 41 (SP) | Acetyl group | Plasma | | 31.185 (Se) | | | | 210,/300 (GF) | | | | | | Plasma | Tachylectin-5B | 41 (SP) | Acetyl group | | | 33.069 (Se) | | | | 21 | | | Big defensin | 8.6 | | L-granule | LEBP-PI | 12 | GNB, GPB, and FN | L-granule | Limulus cystatin | 12.6 | New type | L-granule | Limunectin | 54 | Cystatin family | L-granule | 18 K-LAF | 18 | PC | L-granule | 8.6 kDA protein | 8.6 | Hemocyte aggregation | L-granule | Proxins | 80 | TGase substrate | L-granule | L1 | 11 | TGase substrate | L-granule | L4 | 11 | Unknown Unknown | L-granule |
| Smaller granules | Tachyplesins | 2.3 | GNB,GPB,FN | S-granule | Tachycitin | 8.3 | GNB,GPB,FN | S-granule | Tachystatins | 6.5 | GNB,GPB,FN | S-granule | Big Defensin | 8.6 | GNB,GPB,FN | S-granule | Polyphemusin | 2.3 | GNB,GPB,FN | S-granule |
| Other molecules | Trypsin inhibitor | 6.8 | Kunitz type | ND | LTI | 16 | New type | ND | Chymotrypsin inhibitor | 10 | ND | Plasma | Limulin | 300 | HLA/PC, PE, SA, and KDO | Plasma | LCRP | 300 | PC, PE | Plasma | TCRP-1 | 300 | PE | Plasma | TCRP-2 | 330 | HLA/PE, SA | Plasma | TCRP-3 | 340 | HLA/SA, KDO | Plasma | Polyphemusin | ND | LTA, GlcNAc | Plasma | TTA | ND | SA, GlcNAc | Plasma | Liphemin | 400-500 | SA | Hemolymph | Carcinoscorpin | 420 | SA, KDO | Hemolymph | GBP | 40 | Gal | Hemolymph | PAP | 40 | Protein A | Hemolymph | (1→3) β-D-glucan | 168 | Pachyman | Hemocyte | Transglutaminase(TGase) | 86 | Crosslinking | Cytosol | Limulus kexin | 70 | Precursor processing | ND | Toll-like receptor | 110 | Precursor processing | Hemocyte | (tToll) | | ND | | Hemocyanin | 3600 | Oxygen transporter | Plasma |
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