Mycobacterium avium Infection of Multinucleated Giant Cells Reveals Association of Bacterial Survival to Autophagy and Cholesterol Utilization

Figure 2

Infection and survival of M. avium A5. (a) Percent uptake of M. avium A5 in THP-1 macrophages and MGCs after 1 hour of infection. (b) Fold change relative to 1 h.p.i (dashed line) of M. avium growth over 6 days in THP-1 macrophages. (c) Fold change relative to 1 h.p.i (dashed line) of M. avium growth over 3 days in MGCs. (d) Extracellular bacterial CFUs recovered after infection of MGCs. Data shown are representative of results from three independent biological replicates. Statistical comparisons: ; ; .

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