Analytical Interference by Contrast Agents in Biochemical Assays

Table 2

Assays exhibiting clinically relevant interference by a contrast agent.

	Control	Iodixanol (Visipaque)			Iomeprol (Iomeron)			Gadoxetate disodium (Primovist)
	Median (IQR)	% change	95% CI (%)	value	% change	95% CI (%)	value	% change	95% CI (%)	value
Albumin, g/L	36 (4)	+1.5	0.5 to 2.5	0.0062
Bicarbonate, mmol/L	22 (3)	−3.4	−5.9 to −1.0	0.011	−3.9	−6.3 to −1.4	0.0057
Calcium, mmol/L	2.36 (0.06)	+3.3	2.6 to 4.0	<0.0001	+2.2	1.4 to 3.0	<0.0001
Ionized calcium, mmol/L	1.18 (0.035)	+1.9	0.7 to 3.2	0.0086
Iron, µmol/L	15 (3)	+14.3	10.7 to 17.9	<0.0001				−24.6	−28.7 to −20.5	<0.0001
LDH, U/L	191 (32)	−4.8	−6.2 to −3.5	<0.0001
Magnesium, mmol/L	0.82 (0.03)				−2.7	−3.7 to −1.7	0.0001
Potassium, mmol/L	4 (0.2)	+3.2	1.9 to 4.5	0.0003	+2.3	1.1 to 3.4	0.0012
Sodium, mmol/L	141 (3)	−1.1	−1.5 to −0,7	<0.0001	−1.5	−2.0 to −1.1	<0.0001	+0.5	0.1 to 1.0	0.032
Zinc, µmol/L	10 (2)	−5.1	−8.2 to −2.0	0.0034				−32.6	−36.5 to −28.8	<0.0001

IQR, interquartile range; CI, confidence interval; % change, mean percentage change; LDH, lactate dehydrogenase.