Automated Generation of Reliable Blood Velocity Parameter Maps from Contrast-Enhanced Ultrasound Data

Figure 5

Representative immunohistochemistry images of A549, A431, and MLS tumors. The A549 tumor shows larger, more mature vessels in the tumor periphery, as it can be seen on the magnified image sections I and II. In contrast, the core shows a lower degree of vascularization with smaller vessels. A431 tumors have small immature vessels homogeneously distributed throughout the tumor, as it can be seen on the magnified image sections from the tumor periphery and core. MLS tumors present a more heterogeneous vessel network. This tumor model presents bigger vessels throughout the tumor (I and II). However, directly next to these highly vascularized areas, regions of lower vascularization can be observed (II and III). The scale bars correspond to 600 μm.