CD44v6-Targeted Imaging of Head and Neck Squamous Cell Carcinoma: Antibody-Based Approaches

Figure 3

Preclinical (a–c) and clinical (d–e) images of CD44v6 radionuclide targeting. (a) Representative small animal PET images of a nude mouse bearing two head and neck cancer FaDu xenografts, obtained at 72 h after i.v. injection of the antibody conjugate ⁸⁹Zr–Df–Bz–NCS–cmAb U36 (reprinted and modified from Vosjan et al.) [12]. (b) Representative small animal PET/CT images of nude mice bearing a squamous cell carcinoma A431 xenograft, obtained at 24 h, 48 h, and 72 h after i.v. injection of the human bivalent antibody fragment ¹²⁴I-AbD19384. (c) Representative small animal PET/CT image of a nude mice bearing a squamous cell carcinoma A431 xenograft, obtained at 24 h after i.v. injection of an anti-CD44v6 targeting scFv fragment. (d) Planar imaging of head and neck region of a HNSCC patient 21 h after i.v. injection of the antibody conjugates -cmAb U36 (left) and ¹⁸⁶Re-cmAb U36 (right) (reprinted and modified from Colnot et al. J. Nucl. Med. 2000) [13]. (e) Whole-body scans of a HNSCC patient 1 h, 21 h, 72 h, 144 h, and 2 weeks after i.v. injection of the antibody conjugate ¹⁸⁶Re-cmAb U36 (reprinted and modified from Colnot et al. J. Nucl. Med. 2000) [13].