Gd<sup>3+</sup>-Asparagine-Anionic Linear Globular Dendrimer Second-Generation G2 Complexes: Novel Nanobiohybrid Theranostics

<div>Impact of dendrimer, Magnevist, and Gd3+-dendrimer-asparagine conjugate at a concentration of 160 <i>µ</i>M in expression of Bax and Bcl-2 mRNA levels in HT29 cells. The expression of mRNAs was analyzed by real-time PCR and normalized by<i> GAPDH</i> expression. <svg height="8.68572pt" id="M40" style="vertical-align:-0.0498209pt" version="1.1" viewbox="-0.0498162 -8.6359 8.15071 8.68572" width="8.15071pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z" id="g113-81"></path></g></svg> value less than 0.05 was considered statistically significant for one-way ANOVA analysis followed by Student’s <svg height="8.02022pt" id="M41" style="vertical-align:-0.2063999pt" version="1.1" viewbox="-0.0498162 -7.81382 4.54925 8.02022" width="4.54925pt" 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id="g113-50"></path></g></svg> compared to control.</div>

Contrast Media & Molecular Imaging

fig16

Figure 16

Figure 16: Gd<sup>3+</sup>-Asparagine-Anionic Linear Globular Dendrimer Second-Generation G2 Complexes: Novel Nanobiohybrid Theranostics 

Contrast Media & Molecular Imaging

Gd3+-Asparagine-Anionic Linear Globular Dendrimer Second-Generation G2 Complexes: Novel Nanobiohybrid Theranostics

Figure 16

Gd³⁺-Asparagine-Anionic Linear Globular Dendrimer Second-Generation G2 Complexes: Novel Nanobiohybrid Theranostics