Mapping Extracellular pH of Gliomas in Presence of Superparamagnetic Nanoparticles: Towards Imaging the Distribution of Drug-Containing Nanoparticles and Their Curative Effect on the Tumor Microenvironment

Table 1

Regional analysis for relaxation rate () for all RG2 tumor-bearing rats that underwent coinfusion of TmDOTP⁵⁻ and probenecid (). See Figure 3(a) for details. was measured inside the MRI-defined tumor core (see Figure S2), at the tumor edge (regions 1 mm outside the tumor boundary), and in the healthy/nontumor tissue before and after the infusion of SPIO-NPs. Data shown are mean and standard deviation (SD).

	Intrinsic		TmDOTP^5−		TmDOTP^5− + SPIO-NPs
	Mean	SD	Mean	SD	Mean	SD
Tumor core	22.5	2.1	24.7	2.5	32.7	5.2
Tumor’s edge	22.7	4.0	23.7	4.4	28.6	7.9
Nontumor tissue	23.8	3.8	23.2	3.4	27.3	3.7