Mapping Extracellular pH of Gliomas in Presence of Superparamagnetic Nanoparticles: Towards Imaging the Distribution of Drug-Containing Nanoparticles and Their Curative Effect on the Tumor Microenvironment

Table 2

Regional analysis for extracellular pH (pH_e) imaging before and after infusion of SPIO-NPs for all RG2 tumor-bearing rats that underwent coinfusion of TmDOTP⁵⁻ and probenecid (). See Figure 3(b) for details. The was measured inside the MRI-defined tumor core (see Figure S2), at the tumor edge (regions 1 mm outside the tumor boundary), and in the healthy/nontumor tissue before and after the infusion of SPIO-NPs. Data shown are mean and standard deviation (SD).

	Before SPIO-NPs		After SPIO-NPs
	Mean	SD	Mean	SD
Tumor core	6.9	0.1	6.9	0.1
Tumor’s edge	6.9	0.1	6.9	0.1
Nontumor tissue	7.2	0.1	7.2	0.1