Brain Tumor Diagnostics and Therapeutics with Superparamagnetic Ferrite Nanoparticles

Figure 5

Theoretical and experimental considerations of CED for effective drug delivery. (a) 2D representation of effective convection-enhanced region with intraparenchymal drug injection (small red circle; black dashed line) and CED injected drug (large red oval; black solid line). From [17] with permission. CED in normal rat brain, where the infusate contained GdDTPA²⁻ and Evans blue together, showing examples from three separate rats with different effective convection-enhanced region as depicted by (b) -weighted MRI at of 3.0 T and (c) Evans blue staining for poor, moderate, and efficient CED conditions. From [18] with permission. CED demonstrated with -weighted MRI at of 4.0 T, where the 20 µL infusate contained 0.02 mg, 0.1 mg, and 0.5 mg of SPIO-NPs injected into three normal rats resulting in doses of 1, 5, and 25 mg/kg Fe³⁺, respectively. These respective Fe³⁺ doses were represented as either (d) spin-echo images with an echo time of less than 80 ms and (e) absolute images. The effective volumes were 50 µL, 71 µL, and 76 µL, respectively, based on either the spin-echo images in (d) or images in (e). From [19] with permission.