Table 2

ApplicationsPopulation/animal modelsRadioligandMain findingsRef.

Preclinical6 mice per each group 2-, 4-, and 8-week MCD-fed mice versus control mice18F-FEDACIn 4-week MCD livers, higher binding of tracer was observed at some loci in the right lobe compared to the left liver lobe
Significantly increased uptake ratios of liver to blood in 2-, 4-, and 8-week MCD-fed mice, compared to controls
Strong correlation between uptake ratio of tracer binding and NAFLD activity score was found during NAFLD progression
Xie et al. (2012) [79]

Preclinical4 rats per each group after 2, 4, 6, and 8 weeks of CCl4 treatment versus control rats18F-FEDACSignificantly higher liver tracer SUV in all treatment groups, compared to controls
Tracer binding positively correlated with CCl4 treatment duration and severity of liver damage
Hatori et al. (2015) [80]

MCD, methionine and choline deficient; NAFLD, nonalcoholic fatty liver disease; SUV, standardized uptake value.