TSPO PET Imaging: From Microglial Activation to Peripheral Sterile Inflammatory Diseases?

Table 2

Applications	Population/animal models	Radioligand	Main findings	Ref.
Preclinical	6 mice per each group 2-, 4-, and 8-week MCD-fed mice versus control mice	^18F-FEDAC	In 4-week MCD livers, higher binding of tracer was observed at some loci in the right lobe compared to the left liver lobe; Significantly increased uptake ratios of liver to blood in 2-, 4-, and 8-week MCD-fed mice, compared to controls; Strong correlation between uptake ratio of tracer binding and NAFLD activity score was found during NAFLD progression	Xie et al. (2012) [79]
Preclinical	4 rats per each group after 2, 4, 6, and 8 weeks of CCl4 treatment versus control rats	^18F-FEDAC	Significantly higher liver tracer SUV in all treatment groups, compared to controls; Tracer binding positively correlated with CCl4 treatment duration and severity of liver damage	Hatori et al. (2015) [80]

MCD, methionine and choline deficient; NAFLD, nonalcoholic fatty liver disease; SUV, standardized uptake value.